Understanding antifungal prophylaxis with posaconazole in hematology patients: an evolving bedside to bench story.
نویسندگان
چکیده
Artistic impression of DNA and nucleosome structure. (image created by www.somersault1824.com). 599 Assessing the prognostic impact of immune cell infiltrates in follicular lymphoma Falko Fend, et al. 603 Understanding antifungal prophylaxis with posaconazole in hematology patients: an evolving bedside to bench story Donald C. Sheppard, et al. Review Articles 613 Why methylation is not a marker predictive of response to hypomethylating agents Maria Teresa Voso, et al. 629 The role of positron emission tomography-computed tomography and magnetic resonance imaging in diagnosis and follow up of multiple myeloma Jo Caers, et al. Articles Hematopoiesis 638 In vivo evidence for an instructive role of fms-like tyrosine kinase-3 (FLT3) ligand in hematopoietic development Panagiotis Tsapogas, et al. 647 The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease Sofie Singbrant, et al. 656 Comparison of horse and rabbit antithymocyte globulin in immunosuppressive therapy for refractory cytopenia of childhood Ayami Yoshimi, et al. 664 Long-term outcome after immunosuppressive therapy with horse or rabbit antithymocyte globulin and cyclosporine for severe aplastic anemia in children Dae Chul Jeong, et al.
منابع مشابه
Infectious Complications in Hematology
Post-induction aplasia for acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS) is a period at highrisk for invasive fungal disease (IFD). Invasive aspergillosis (IA) remains the commonest cause of IFD and crude mortality remains considerable at 33-47%. For patients surviving IFDs, delays or modifications to curative chemotherapy may compromise long-term prognosis. Poor clinical outcome...
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In a recent Editorial on the role of antifungal treatment in hematology, Maertens et al. analyzed the diagnostic and therapeutic antifungal strategies which are used in particular in neutropenic patients. Among the various topics covered, some observations concerned antifungal prophylaxis. They underlined some critical issues of antifungal prophylaxis including the lack of evidence of its impac...
متن کاملClinical effectiveness of posaconazole versus fluconazole as antifungal prophylaxis in hematology–oncology patients: a retrospective cohort study
In preventing invasive fungal disease (IFD) in patients with acute myelogenous leukemia (AML) or myelodysplastic syndrome (MDS), clinical trials demonstrated efficacy of posaconazole over fluconazole and itraconazole. However, effectiveness of posaconazole has not been investigated in the United States in real-world setting outside the environment of controlled clinical trial. We performed a si...
متن کاملRhabdomyolysis Following Initiation of Posaconazole Use for Antifungal Prophylaxis in a Patient With Relapsed Acute Myeloid Leukemia: A Case Report.
Posaconazole is a commonly used medication for antifungal prophylaxis in patients with high-risk acute leukemia, such as acute myeloid leukemia. Despite clinical data that show that posaconazole is superior to other antifungal prophylaxis medications, posaconazole is known to have many side effects and drug-drug interactions. We present a patient who developed rhabdomyolysis after being started...
متن کاملRhabdomyolysis Following Initiation of Posaconazole Use for Antifungal Prophylaxis in a Patient With Relapsed Acute Myeloid Leukemia
Posaconazole is a commonly used medication for antifungal prophylaxis in patients with high-risk acute leukemia, such as acute myeloid leukemia. Despite clinical data that show that posaconazole is superior to other antifungal prophylaxis medications, posaconazole is known to have many side effects and drug-drug interactions. We present a patient who developed rhabdomyolysis after being started...
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ورودعنوان ژورنال:
- Haematologica
دوره 99 4 شماره
صفحات -
تاریخ انتشار 2014